3,4-Dimethoxybenzeneacetonitrile → HCID 10018827, compound

HRID 2222349Notes

Reaction equation

HRID 2222349 reaction equation
[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH2:17][C:18]#[N:19]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16](/[C:17](=[CH:4]/[C:3]2[CH:6]=[C:7]([F:11])[CH:8]=[C:9]([F:10])[C:2]=2[F:1])/[C:18]#[N:19])[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 27769502,3,5-Trifluorobenzaldehyde

Product 1

HCID 10018827HCID 10018827, compoundYield 84%

Procedure

2,3,5-Trifluorobenzaldehyde (320 mg) and 3,4-dimethoxybenzyl cyanide (354 mg) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (536 mg, yield: 84%).

Sources & evidence

ORD record
ord-b3cbf3d4c74e47ad836b24bac6148017
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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