3,4-Dimethoxybenzeneacetonitrile → HCID 10381255, compound

HRID 2222352Notes

Reaction equation

HRID 2222352 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1[F:10])[CH:5]=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH2:17][C:18]#[N:19]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16](/[C:17](=[CH:5]/[C:4]2[CH:3]=[C:2]([F:1])[C:9]([F:10])=[C:8]([F:11])[CH:7]=2)/[C:18]#[N:19])[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 27769543,4,5-Trifluorobenzaldehyde

Product 1

HCID 10381255HCID 10381255, compoundYield 19%

Procedure

3,4,5-Trifluorobenzaldehyde (160 mg) and 3,4-dimethoxybenzyl cyanide (177 mg) were subjected to condensation in accordance with process B of (production process 2), to thereby produce the target product (60 mg, yield: 19%).

Sources & evidence

ORD record
ord-f4f1d5763d9546b3beda1f07ce9963b3
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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