3,4-Dimethoxybenzeneacetonitrile → HCID 10380110, compound

HRID 2222353Notes

Reaction equation

HRID 2222353 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=O.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:16][C:17]#[N:18]>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1/[CH:4]=[C:16](/[C:15]1[CH:19]=[CH:20][C:21]([O:22][CH3:23])=[C:13]([O:12][CH3:11])[CH:14]=1)\[C:17]#[N:18]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 1362842,6-Difluorobenzaldehyde

Product 1

HCID 10380110HCID 10380110, compoundYield 59.5%

Procedure

2,6-Difluorobenzaldehyde (284 mg) and 3,4-dimethoxybenzyl cyanide (354 mg) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (358 mg, yield: 40%).

Sources & evidence

ORD record
ord-145eb9c0f2ac4b6b9794081b32e56a03
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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