(3,5-Bis(trifluoromethyl)phenyl)acetonitrile → (z)-2-(3,5-Bis-trifluoromethyl-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile

Participants

Role	Name	HCID	Charge
Reactant	(3,5-Bis(trifluoromethyl)phenyl)acetonitrile	HCID 603657	—
Reactant	Benzaldehyde, 4-[(2-methoxyethoxy)methoxy]-	HCID 11401561	—
Product	(z)-2-(3,5-Bis-trifluoromethyl-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile	HCID 9998426	17.1%

Reaction Steps

4-Methoxyethoxymethoxybenzaldehyde (420 mg) and 3,5-bis(trifluoromethyl)phenylacetonitrile (506 mg) were subjected to condensation in accordance with process A of (production process 2), and the resultant product was subjected to deprotection in accordance with (production process 3), to thereby produce the target product (122 mg, yield: 17%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07371773B2
Source dataset	uspto-grants-2008_05
ORD ID	ord-1bc2f3c711b747e69667d3a3d7eb8dcf
Source note	uspto-grants-2008_05