3,4-Dimethoxybenzeneacetonitrile → HCID 10450778, compound

HRID 2222368Notes

Reaction equation

HRID 2222368 reaction equation
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:5]=1[CH:6]=O)[CH3:2].[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:20][C:21]#[N:22]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19](/[C:20](=[CH:6]/[C:5]2[CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=[CH:11][C:4]=2[O:3][CH2:1][CH3:2])/[C:21]#[N:22])[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 47665422-ethoxy-5-nitrobenzaldehyde

Product 1

HCID 10450778HCID 10450778, compoundYield 45.1%

Procedure

2-Ethoxy-5-nitrobenzaldehyde (390 mg) and 3,4-dimethoxybenzyl cyanide (354 mg) were subjected to condensation in accordance with process B of (production process 2), to thereby produce the target product (319 mg, yield: 45%).

Sources & evidence

ORD record
ord-34c01777dc69449988fa97d045a2d236
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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