3,4-Dimethoxybenzeneacetonitrile → HCID 69269658, compound

Participants

Reaction Steps

The hydroxyl group of 3-hydroxy-4-nitrobenzaldehyde (0.67 g) was protected by use of 2-methoxyethoxymethyl chloride (0.50 g) in accordance with (production process 1), to thereby produce an MEM form (0.97 g, yield: 95%). The resultant MEM form (944 mg) and 3,4-dimethoxybenzyl cyanide (673 mg) were subjected to condensation in accordance with process B of (production process 2), to thereby produce (Z)-2-(3,4-dimethoxy-phenyl)-3-[3-(2-methoxy-ethoxymethoxy)-4-nitro-phenyl]-acrylonitrile (515 mg, yield: 34%). The thus-produced (Z)-2-(3,4-dimethoxy-phenyl)-3-[3-(2-methoxy-ethoxymethoxy)-4-nitro-phenyl]-acrylonitrile (350 mg) was subjected to deprotection in accordance with (production process 3), to thereby produce the target product (267 mg, yield: 97%).

Provenance & Evidence