3,4-Dimethoxybenzeneacetonitrile → HCID 23089835, compound

Participants

Reaction Steps

The hydroxyl group of 3-fluoro-2-hydroxybenzaldehyde (560 mg) was protected by use of 2-methoxyethoxymethyl chloride (500 mg) in accordance with (production process 1), to thereby produce an MEM form (660 mg, yield: 72%). The resultant MEM form (650 mg) and 3,4-dimethoxybenzyl cyanide (500 mg) were subjected to condensation in accordance with process A of (production process 2), to thereby produce (Z)-2-(3,4-dimethoxy-phenyl)-3-(3-fluoro-2-methoxyethoxymethoxy-phenyl)-acrylonitrile (680 mg, yield: 58%). The thus-produced (Z)-2-(3,4-dimethoxy-phenyl)-3-(3-fluoro-2-methoxyethoxymethoxy-phenyl)-acrylonitrile (670 mg) was subjected to deprotection in accordance with (production process 3), to therey produce the target product (140 mg, yield: 29%).

Provenance & Evidence