3,4-Dimethoxybenzeneacetonitrile → HCID 69274237, compound

Participants

Reaction Steps

The hydroxyl group of 3-fluoro-4-hydroxybenzaldehyde (3.92 g) was protected by use of 2-methoxyethoxymethyl chloride (3.49 g) in accordance with (production process 1), to thereby produce an MEM form (4.98 g, yield: 78%). The resultant MEM form (4.98 g) and 3,4-dimethoxybenzyl cyanide (3.87 g) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (6.55 g, yield: 78%).

Provenance & Evidence