Pyridine → HCID 69274201, compound

HRID 2222377Notes

Reaction equation

HRID 2222377 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[C:11](=[CH:14]/[C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([F:22])[CH:16]=2)/C#N)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[C:23]([O:26]C(=O)C)(=O)[CH3:24].[N:30]1C=CC=C[CH:31]=1>>[C:23]([O:21][C:18]1[CH:19]=[CH:20][C:15](/[C:14](/[C:31]#[N:30])=[CH:11]/[C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:16][C:17]=1[F:22])(=[O:26])[CH3:24]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 10017615HCID 10017615, compound

Product 1

HCID 69274201HCID 69274201, compoundYield 92%

Procedure

Compound 59 (1.20 g) was acetylated with acetic anhydride and pyridine in accordance with a customary method, to thereby produce the target product (1.26 g, yield: 92%).

Sources & evidence

ORD record
ord-e7fe87c8d120414ab4f2de5ef58c0141
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

Loading…