3,4-Dimethoxybenzeneacetonitrile → HCID 10042133, compound

HRID 2222384Notes

Reaction equation

HRID 2222384 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:18][C:19]#[N:20]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[C:18](=[CH:6]/[C:5]2[CH:8]=[CH:9][C:2]([F:1])=[C:3]([N+:10]([O-:12])=[O:11])[CH:4]=2)/[C:19]#[N:20])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 5981294-Fluoro-3-nitrobenzaldehyde

Product 1

HCID 10042133HCID 10042133, compoundYield 49.3%

Procedure

4-Fluoro-3-nitrobenzaldehyde (507 mg) and 3,4-dimethoxybenzyl cyanide (532 mg) were subjected to condensation in accordance with process B of (production process 2), to thereby produce the target product (485 mg, yield: 30%).

Sources & evidence

ORD record
ord-acc783ceb87744ee8737f7a5bb9dccc7
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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