HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222391Generated: October 27, 2026
Hydrochloric Acid → 6-Cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)-4-(indol-5-ylamino)quinoline hydrochloride
https://huagongshe.com/reaction/2222391
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Aminoindole | HCID 78867 | — |
| Reactant | 4-Chloro-6-cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline | HCID 59712236 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | 2-Pentanol | HCID 22386 | — |
| Product | 6-Cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)-4-(indol-5-ylamino)quinoline hydrochloride | HCID 69135036 | 96.7% |
Reaction Steps
A solution of 4-chloro-6-cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline (80 mg, 0.21 mmol) and 5-aminoindole (33 mg, 0.25 mmol) in 2-pentanol (2.5 ml) containing 6.2N HCl in isopropanol (40 μl) was heated at 120° C. for 3 hours. After cooling, the solid was collected by filtration, washed with isopropanol followed by ether and dried under vacuum to give 6-cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)-4-(indol-5-ylamino)quinoline hydrochloride (104 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07371765B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-470645d8c49b497c9ade6c2107e93537 |
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| Source note | uspto-grants-2008_05 |
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