HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dimethyl-1H-indol-5-ol → 6-Cyano-4-(2,3-dimethylindol-5-yloxy)-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dimethyl-1H-indol-5-ol | HCID 22030788 | — |
| Reactant | 4-Chloro-6-cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline | HCID 59712236 | — |
| Product | 6-Cyano-4-(2,3-dimethylindol-5-yloxy)-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline | HCID 10141972 | 64.8% |
Reaction Steps
Using an analogous procedure to that described in Example 7, 4chloro-6-cyano-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline (100 mg, 0.26 mmol) was reacted with 2,3-dimethyl-5-hydroxyindole (51 mg, 0.32 mmol), (Arch. Pharm. 1972, 305, 159), to give 6-cyano-4-(2,3-dimethylindol-5-yloxy)-7-(3-(1,1-dioxothiomorpholino)propoxy)quinoline (85 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371765B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-5f0b9cc12062495d967a22972135edf5 |
| Source note | uspto-grants-2008_05 |