反应详情

温度

100 °C

To a solution of 3-phenyl-1H-pyrazole (300 mg) in toluene (15 mL) were added tert-butyl 4-hydroxypiperidine-1-carboxylate (838 mg) and (tributylphosphoranylidene)acetonitrile (1.0 g), followed by stirring at 100° C. for 4 hours. The reaction liquid was concentrated under reduced pressure, and then the residue was purified by silica gel column chromatography (hexane/ethyl acetate=100/0 to 50/50) and purified again by silica gel column chromatography (hexane/ethyl acetate=100/0 to 70/30) to obtain tert-butyl 4-(3-phenyl-1H-pyrazol-1-yl)piperidine-1-carboxylate (475 mg) as a colorless oily substance.

1. customThe reaction liquid
2. concentrationwas concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=100/0 to 50/50)
4. custompurified again by silica gel column chromatography (hexane/ethyl acetate=100/0 to 70/30)