4-fluoro-2-methyl-1H-indol-5-ol → 6-Cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline

Participants

Reaction Steps

Using an analogous procedure to that described in Example 11, 4-chloro-6-cyano-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline (500 mg, 1.45 mmol) was reacted with 4-fluoro-5-hydroxy-2-methylindole (287 mg, 1.74 mmol), (prepared as described for the starting material in Example 11), in DMF (1 ml) to give 6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline (304 mg, 44%).

Provenance & Evidence