3-(Methylsulfonyl)-1-propanol → 4-Chloro-6-cyano-7-(3-methylsulphonylpropoxy)quinoline

Participants

Reaction Steps

Using an analogous procedure to that described for the preparation of the starting material in Example 15, (see note a) above), 4-chloro-6-cyano-7-hydroxyquinoline (300 mg, 1.46 mmol), (prepared as described for the starting material in Example 1), was reacted with 3-(methylsulphonyl)-1-propanol (263 mg, 1.9 mmol) and the crude product was purified using a gradient of methylene chloride/ethyl acetate (1/1) to (2/8) to give 4-chloro-6-cyano-7-(3-methylsulphonylpropoxy)quinoline (428 mg, 90%)

Provenance & Evidence