2,3-Dimethyl-1H-indol-5-ol → 6-Cyano-4-(2,3-dimethylindol-5-yloxy)-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline

Participants

Reaction Steps

Using an analogous procedure to that described in Example 20, 4-chloro-6-cyano-7-(3-(4methylpiperazin-1-yl)propoxy)quinoline (150 mg, 0.44 mmol), (prepared as described for the starting material in Example 12), was reacted with 2,3-dimethyl-5-hydroxyindole (84 mg, 0.52 mmol), (Arch. Pharm. 1972, 305, 159), to give 6-cyano-4-(2,3-dimethylindol-5-yloxy)-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline (146 mg, 60%).

Provenance & Evidence