Triphenylphosphine → HCID 178457566, compound

Participants

Reaction Steps

To a mixture of OZ277 free base (0.46 g, 1.17 mmol), triphenylphosphine (0.77 g, 2.94 mmol), and trimethylsilyl azide (0.34 g, 2.95 mmol) in THF (20 ml) at 0° C. under N2 was added dropwise diisopropyl azodicarboxylate (0.71 g, 3.51 mmol). The mixture was slowly warmed to rt and stirred for 72 h. The reaction mixture was diluted with water (50 ml) and extracted with EtOAc (2×50 ml). The combined extracts were washed with saturated aqueous NaHCO3 (2×50 ml) and brine (50 ml), dried over MgSO4, filtered, and concentrated. To a solution of the residue CHCl3 (20 ml) was added a solution of p-toluenesulfonic acid monohydrate (0.22 g) in ethanol (10 ml). After evaporation of the solvents, the crude product was purified by crystallization from MeOH/CH2Cl2 (1:4) to afford trioxolane OZ373 (0.12 g, 17%) as a colorless solid. mp 220° C. dec; 1H NMR (500 MHz, CD3OD) δ1.28-1.38 (m, 2H), 1.38 (s, 6H), 1.65-2.09 (m, 21H), 2.37 (s, 3H), 2.86 (d, J=6.8 Hz, 2H), 4.58 (s, 2H), 7.23 (d, J=7.8 Hz, 2H), 7.70 (d, J=7.8 Hz, 2H); 13C NMR (125.7 MHz, CD3OD) δ21.30, 23.79, 27.97, 28.37, 30.04, 30.87, 34.87, 35.77, 35.78, 36.04, 37.80, 37.88, 54.02, 55.39, 109.53, 112.40, 126.97, 129.81, 141.66, 157.09.

Provenance & Evidence