Hydrochloric Acid → HCID 59712339, compound

Participants

Reaction Steps

To a solution of 0.974 g of methyl 1-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxybenzoyl)-1-cyclopropanecarboxylate in 30 ml of ethanol and 10 ml of tetrahydrofuran was added 0.112 g of sodium borohydride, and the mixture was stirred at room temperature for 15 hours. 50 ml of water, 100 ml of ethyl acetate and 5 ml of hydrochloric acid (2N) were added, and the organic layer was dried over magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography, to give 0.483 g of the title compound as a colorless oil.

Provenance & Evidence