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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222491Generated: November 1, 2026

4-Methylmorpholine → HCID 178427200, compound

https://huagongshe.com/reaction/2222491

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylmorpholineHCID 7972—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant3-Methyl-4-(3-oxomorpholin-4-yl)benzoic acidHCID 67048526—
Reactant(1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamineHCID 178511832—
SolventDimethylformamideHCID 6228—
ProductHCID 178427200HCID 178427200—

Reaction Steps

Prepared analogously to Example 1f from 3-methyl-4-(morpholin-3-on-4-yl)-benzoic acid, (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxy-ethylamine, TBTU and NMM in DMF with subsequent purification by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07371743B2
Source datasetuspto-grants-2008_05
ORD IDord-50dde675154e47f0bc057c150441c302
Source noteuspto-grants-2008_05