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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222515Generated: November 2, 2026

Trifluoroacetic acid → (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamine

https://huagongshe.com/reaction/2222515

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 178495124HCID 178495124—
SolventDichloromethaneHCID 6344—
Product(S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamineHCID 178495121—

Reaction Steps

Prepared analogously to Example 1g from (1S)-N-Boc-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxy-propylamine and TFA in dichloromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07371743B2
Source datasetuspto-grants-2008_05
ORD IDord-058cf065afc84cfc9afe7077529e5c73
Source noteuspto-grants-2008_05