Potassium Hydroxide → 4-(4,4-Dimethyl-2-oxo-imidazolidin-1-yl)-3-methyl-benzoic acid

HRID 2222538Notes

Reaction equation

HRID 2222538 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:6][N:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=2[CH3:17])[C:4](=[O:18])[NH:3]1.[OH-].[K+]>CO.O>[CH3:1][C:2]1([CH3:19])[CH2:6][N:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=2[CH3:17])[C:4](=[O:18])[NH:3]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 67048320Methyl 4-(4,4-dimethyl-2-oxo-imidazolidin-1-yl)-3-methyl-benzoate

Product 1

HCID 667315354-(4,4-Dimethyl-2-oxo-imidazolidin-1-yl)-3-methyl-benzoic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2.70 g (10.3 mmol) methyl 4-(4,4-dimethyl-2-oxo-imidazolidin-1-yl)-3-methyl-benzoate are suspended in 75 ml of methanol and combined with a solution of 1.68 g (30.0 mmol) potassium hydroxide in 10 ml of water. It is stirred for 3 hours at ambient temperature and then evaporated down i. vac. The aqueous residue is diluted with water, acidified with 1-molar hydrochloric acid and the precipitate obtained is suction filtered, washed with water and dried.

Workup

  1. customevaporated down i
  2. additionThe aqueous residue is diluted with water
  3. customthe precipitate obtained
  4. filtrationfiltered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-562090e680464d8582606a2578766f4d
Source dataset
uspto-grants-2008_05
Patent number
US07371743B2

Reaction notes

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