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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222549Generated: October 29, 2026

Dimethylformamide → 3-Fluoro-4-(morpholin-3-on-4-yl)benzoic acid-chloride

https://huagongshe.com/reaction/2222549

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantThionyl ChlorideHCID 24386—
Reactant4-(2-Carboxymethoxy-ethylamino)-3-fluoro-benzoic acidHCID 66731590—
SolventDichloromethaneHCID 6344—
Product3-Fluoro-4-(morpholin-3-on-4-yl)benzoic acid-chlorideHCID 86069379—

Reaction Steps

Prepared analogously to Example 41c from 4-(2-carboxymethoxy-ethylamino)-3-fluoro-benzoic acid and thionylchoride in dichloromethane with DMF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07371743B2
Source datasetuspto-grants-2008_05
ORD IDord-22891a75173042fe88f77edd9993467c
Source noteuspto-grants-2008_05