5-Nitro-7-azaindole → 1H-pyrrolo(2,3-b)pyridin-5-amine

Participants

Reaction Steps

To a solution of 5-nitro-1H-pyrrolo[2,3-b]pyridine (0.4 g, 2.45 mmol) in ethyl acetate (100 mL) 5% Pd—C (0.3 g) was added and the mixture subdued to hydrogenation (30 psi) in a Parr apparatus. After 4 hours the catalyst was filtered off through celite, the cake was washed with ethyl acetate and then with a mixture of dichloromethane/methanol 4:1. 1H-pyrrolo[2,3-b]pyridin-5-amine (5-aminoazaindole) was obtained in 95% yield (0.31 g, 2.33 mmol).

Provenance & Evidence