N-bromobutanimide → HCID 59713001, compound

HRID 2222750Notes

Reaction equation

HRID 2222750 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)[CH3:6])[CH3:2].[Br:18]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:17])[C:5]([Br:18])([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:15])([F:16])[F:14])[CH:8]=1)[CH3:6])[CH3:2]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 59713008HCID 59713008, compound

Product 1

HCID 59713001HCID 59713001, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

The ester 51 (0.05 mol) was dissolved in carbon tetrachloride (75 mL) and N-bromosuccinimide (0.05 mol) was added. The mixture was heated at reflux and the progress of the reaction was monitored by TLC. When the reaction was complete, the mixture was cooled and filtered. The solution was concentrated to afford the title compound 52.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux
  3. temperaturethe mixture was cooled
  4. filtrationfiltered
  5. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-ed786e8b817b465fb620393f4c36a833
Source dataset
uspto-grants-2008_05
Patent number
US07371888B2

Reaction notes

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