HCID 4713007, compound → HCID 59713021, compound

HRID 2222756Notes

Reaction equation

HRID 2222756 reaction equation
[CH3:1][O:2][C:3](=[O:18])[CH:4](Br)[C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([S:15][CH3:16])[CH:6]=1.[N+:19]([C:22]1[CH:27]=[CH:26][C:25]([SH:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=1)([O-:21])=[O:20]>>[CH3:1][O:2][C:3](=[O:18])[CH:4]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([S:15][CH3:16])[CH:6]=1)[S:28][C:25]1[CH:26]=[CH:27][C:22]([N+:19]([O-:21])=[O:20])=[CH:23][C:24]=1[C:29]([F:30])([F:31])[F:32]

Participants

3

Reactant 2

HCID 4713007HCID 4713007, compoundHCID 59713000HCID 59713000, compound

Product 1

HCID 59713021HCID 59713021, compound

Procedure

Using the procedures of Example 1, bromo-(3-methylsulfanyl-5-trifluoromethyl-phenyl)-acetic acid methyl ester 106 and 4-nitro-2-trifluoromethyl-benzenethiol 107, prepared as described in Preparation 7 were combined to form (3-methylsulfanyl-5-trifluoromethyl-phenyl)-(4-nitro-2-trifluoromethyl-phenylsulfanyl)-acetic acid methyl ester, 108, which was then hydrolyzed under basic conditions to afford the title compound 109.

Workup

  1. customprepared
  2. customas described in Preparation 7

Sources & evidence

ORD record
ord-6d220c00fe594063bc3316c4bddb1699
Source dataset
uspto-grants-2008_05
Patent number
US07371888B2

Reaction notes

Loading…