2-Bromo-5-nitrobenzoic acid → 5-Amino-2-bromobenzoic acid

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Reaction Steps

A mixture of 2-bromo-5-nitrobenzoic acid (1.10 g, 4.06 mmol)(Aldrich, 38, 184-5), activated Pd—C (43.62 mg, 0.41 mmol) (Aldrich, 20, 569-9) in methanol (30 ml) was hydrogenated for 4 hr under 30 psi of hydrogen pressure. After the mixture was filtered, the filtrate was concentrated to give 0.80 g (91.2% yield) of 5-amino-2-bromobenzoic acid as a pale yellow solid.

Provenance & Evidence