HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 5-(2,3,5,6-Tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| Reactant | 5-amino-2-(trifluoromethoxy)benzoic Acid | HCID 11830994 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(2,3,5,6-Tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid | HCID 10049466 | 81% |
Reaction Steps
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-trifluoromethoxybenzoic acid (1.35 g, 6.23 mmole), DMF (50 ml), TEA (6 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.10 ml, 6.7.3 mmole), 2.25 g (81.0% yield) of 5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371896B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-9f1ff4bc70c0477c96e93bfd3e410121 |
| Source note | uspto-grants-2008_05 |