Water → HCID 58664764, compound

Participants

Reaction Steps

81.3 g of NaHCO3 are added in small portions to a solution of 206.4 g of (S)-3-nitrotyrosine ethyl ester tosylate in 750 of water and 250 ml of THF. A solution of 60 ml of 2,2-dimethylpropyl chloroformate (neopentyl chloroformate) in 250 ml of THF is then slowly added dropwise, and the mixture is stirred at room temperature for a further 2 hours. After removal of the solvent, the mixture is subjected to conventional work-up, giving 12.

Provenance & Evidence