HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetoacetic Acid → Atorvastatin lactone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetoacetic Acid | HCID 96 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dioxo-heptanoic acid, ethyl ester | HCID 11330705 | — |
| Product | Atorvastatin lactone | HCID 6483036 | — |
Reaction Steps
In a process analogous to Step 5 METHOD A, by substituting the appropriate ester or amide of acetoacetic acid for ethyl acetoacetate, one obtains the following compounds:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371855B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-73ba4034602d421190a82f6306f5e336 |
| Source note | uspto-grants-2008_05 |