2-Chloronicotinic acid → HCID 86596148, compound

Participants

Reaction Steps

To a mixture of 2-chloronicotinic acid (20 mg, 0.112 mmol), and trans-N-cyanomethyl-2-[4-(aminoethylsulfanyl)benzenesulfonylmethyl]cyclohexanecarboxamide (50 mg, 0.102 mmol) in tetrahydrofuran (1 mL) was added diisopropylethylamine (71 μL, 0.407 mmol). The reaction mixture was stirred overnight at room temperature, then purified directly on a short plug of silica gel (0-10% methanol/dichloromethane) to give the title compound. MS [ESI, (M+H)+] m/z 535 amu, MS [ESI, (M+Na)+] m/z=557 amu.

Provenance & Evidence