Diisopropylethylamine → HCID 86596150, compound

Participants

Reaction Steps

To a mixture of isonicotinoyl hydrochloride (20 mg, 0.112 mmol) and trans-N-cyanomethyl-2-[4-(aminoethylsulfanyl)benzenesulfonylmethyl]cyclohexanecarboxamide (50 mg, 0.102 mmol) in tetrahydrofuran (1 mL) was added diisopropylethylamine (71 μL, 0.407 mmol). The reaction mixture was stirred overnight at room temperature, then purified directly on a short plug of silica gel (5-10% methanol/dichloromethane) to give the title compound. MS [ESI, (M+H)+] m/z=501 amu.

Provenance & Evidence