Water → HCID 68801930, compound

Participants

Reaction Steps

To a solution of (S)-3-benzooxazol-5-yl-2-tert-butoxycarbonylamino-propionic acid ethyl ester (0.54 g, 1.61 mmol) in tetrahydrofuran (10 mL) was added water (5 mL) and lithium hydroxide monohydrate (111 mg, 2.65 mmol) and the mixture stirred at ambient temperature under argon for 1 hour. The reaction mixture was poured into water (50 mL), diluted with brine (25 mL) and extracted with ethyl acetate (3×25 mL). The combined organic extracts were washed with brine (50 mL), dried over sodium sulfate and concentrated in vacuo to give crude (S)-3-benzooxazol-5-yl-2-tert-butoxycarbonylamino-propionic acid an off white solid foam which was used without further purification (0.49 g, 99%).

Provenance & Evidence