2-Acetylpyridine → 2-[3-(4-methoxyphenyl)-1-oxoprop-2-enyl]pyridine

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Reaction Steps

7.4 g 2-acetylpyridine is added to a solution of 8.3 g 4-methoxybenzaldehyde in 100 ml methanol at 0° C. 100 ml of a 2 N sodium hydroxide solution is added with strong agitation. After 14 hours of agitation at room temperature, the yellow precipitate is filtered off, washed with 10 ml methanol and washed three times with 50 ml water, and dried in a vacuum.

Provenance & Evidence