HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-nitro-2-furoate → Methyl 5-aminofuran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-nitro-2-furoate | HCID 94882 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 5-aminofuran-2-carboxylate | HCID 5072225 | — |
Reaction Steps
A solution of 100 mg of methyl 5-nitro-2-furoate (Lancaster Synthesis, Windham, N.H., USA) in 20 ml of EtOAc was stirred with 20 mg of Pd/C (10%) under one atmospheric pressure of hydrogen gas. After at RT for 2 hours, the mixture was filtered through a celite pad and concentrated. Pure methyl 5-amino-2-furoate was obtained by purification on a fresh silica gel column eluted with 30% EtOAc in hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375078B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-92b25acab098427f836fac8da880d497 |
| Source note | uspto-grants-2008_05 |