HCID 131726793, compound → HCID 131726795, compound

HRID 2223022Notes

Reaction equation

HRID 2223022 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:15]([NH:17][C@H:18]([C:31](ON1C(=O)CCC1=O)=[O:32])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26]C(C)(C)C)=[CH:22][CH:21]=1)=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10]C(C)(C)C)=[CH:6][CH:5]=1.[NH2:48][C@H:49]([C:54]([OH:56])=[O:55])[C@H:50]([CH2:52][CH3:53])[CH3:51].[CH3:57][N:58]1[C@@H:75]2[CH2:76][C:63]3[CH:64]=[CH:65][C:66]([O:77][CH3:78])=[C:67]4[O:68][C@H:69]5[C:70]([CH2:72][CH2:73][C@@H:74]2[C@:61]5([C:62]=34)[CH2:60][CH2:59]1)=[O:71]>>[NH2:1][C@H:2]([C:15]([NH:17][C@H:18]([C:31]([NH:48][C@H:49]([C:54]([OH:56])=[O:55])[C@H:50]([CH2:52][CH3:53])[CH3:51])=[O:32])[CH2:19][C:20]1[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=1)=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[CH3:57][N:58]1[C@@H:75]2[CH2:76][C:63]3[CH:64]=[CH:65][C:66]([O:77][CH3:78])=[C:67]4[O:68][C@H:69]5[C:70]([CH2:72][CH2:73][C@@H:74]2[C@:61]5([C:62]=34)[CH2:60][CH2:59]1)=[O:71]

Participants

3

Reactant 2

HCID 131726793HCID 131726793, compoundHCID 131726796HCID 131726796, compound

Product 1

HCID 131726795HCID 131726795, compound

Procedure

Tyr-Tyr-Ile-Hydrocodone was prepared by a similar method to Example 9 except the amino acid starting material was Boc-Tyr(tBu)-Tyr(tBu)-OSu and the conjugate starting material was Ile-Hydrocodone.

Sources & evidence

ORD record
ord-41aaa01dc8c744a2a17a2107a6fa22ca
Source dataset
uspto-grants-2008_05
Patent number
US07375082B2

Reaction notes

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