HCID 14258383, compound → HCID 131726792, compound

HRID 2223032Notes

Reaction equation

HRID 2223032 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:22][CH2:21][CH2:20][C@H:2]1[C:3]([N:5]1[CH2:19][CH2:18][CH2:17][C@H:6]1[C:7]([O:9]N1C(=O)CCC1=O)=O)=[O:4].[NH2:30][C@H:31]([C:36]([OH:38])=[O:37])[C@H:32]([CH2:34][CH3:35])[CH3:33].[CH3:39][N:40]1[C@@H:57]2[CH2:58][C:45]3[CH:46]=[CH:47][C:48]([O:59][CH3:60])=[C:49]4[O:50][C@H:51]5[C:52]([CH2:54][CH2:55][C@@H:56]2[C@:43]5([C:44]=34)[CH2:42][CH2:41]1)=[O:53]>>[NH:1]1[CH2:22][CH2:21][CH2:20][C@H:2]1[C:3]([N:5]1[CH2:19][CH2:18][CH2:17][C@H:6]1[C:7]([NH:30][C@H:31]([C:36]([OH:38])=[O:37])[C@H:32]([CH2:34][CH3:35])[CH3:33])=[O:9])=[O:4].[CH3:39][N:40]1[C@@H:57]2[CH2:58][C:45]3[CH:46]=[CH:47][C:48]([O:59][CH3:60])=[C:49]4[O:50][C@H:51]5[C:52]([CH2:54][CH2:55][C@@H:56]2[C@:43]5([C:44]=34)[CH2:42][CH2:41]1)=[O:53]

Participants

3

Reactant 2

HCID 14258383HCID 14258383, compoundHCID 131726793HCID 131726793, compound

Product 1

HCID 131726792HCID 131726792, compound

Procedure

Pro-Pro-Ile-Hydrocodone was prepared by a similar method to Example 41 except the amino acid starting material was Boc-Pro-Pro-OSu and the conjugate starting material was Ile-Hydrocodone.

Sources & evidence

ORD record
ord-7ee01266783047e08f79d79c3b99943c
Source dataset
uspto-grants-2008_05
Patent number
US07375083B2

Reaction notes

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