tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate → HCID 86622284, compound

HRID 2223123Notes

Reaction equation

HRID 2223123 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:14])([CH2:12][CH3:13])[CH2:10][CH3:11].[C:15]([O:19][C:20](=[O:28])[NH:21][C:22]([CH3:27])([CH3:26])[CH2:23][CH:24]=O)([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20](=[O:28])[NH:21][C:22]([CH3:27])([CH3:26])[CH2:23][CH2:24][NH:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH2:12][CH3:13])([OH:14])[CH2:10][CH3:11])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 11788901tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamateHCID 21072832HCID 21072832, compound

Product 1

HCID 86622284HCID 86622284, compound

Procedure

The product is obtained analogously to intermediate product 1b starting from 3-(2-amino-4-fluorophenyl)pentan-3-ol and tert-butyl(1,1-dimethyl-3-oxopropyl)carbamate. The crude product is purified by column chromatography (silica gel, dichloromethane/MeOH 100:0→98:2). Yield: 7.70 g (99%).

Workup

  1. customThe crude product is purified by column chromatography (silica gel, dichloromethane/MeOH 100:0→98:2)

Sources & evidence

ORD record
ord-ad834c527da54e338d86a52d4ccc8a4f
Source dataset
uspto-grants-2008_05
Patent number
US07375104B2

Reaction notes

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