tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate → HCID 86600981, compound

HRID 2223124Notes

Reaction equation

HRID 2223124 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]([OH:15])([CH2:13][CH3:14])[CH2:11][CH3:12].[C:16]([O:20][C:21](=[O:29])[NH:22][C:23]([CH3:28])([CH3:27])[CH2:24][CH:25]=O)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21](=[O:29])[NH:22][C:23]([CH3:28])([CH3:27])[CH2:24][CH2:25][NH:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]([CH2:13][CH3:14])([OH:15])[CH2:11][CH3:12])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 11788901tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamateHCID 21072831HCID 21072831, compound

Product 1

HCID 86600981HCID 86600981, compound

Procedure

The product is obtained analogously to intermediate product 1b starting from 3-(2-amino-3-methoxyphenyl)pentan-3-ol and tert-butyl(1,1-dimethyl-3-oxopropyl)carbamate. The crude product is purified by column chromatography (silica gel, cyclohexane/EtOAc, 4:1). Yield: 4.60 g (47%).

Workup

  1. customThe crude product is purified by column chromatography (silica gel, cyclohexane/EtOAc, 4:1)

Sources & evidence

ORD record
ord-67ef660feca848718fb78d0873361660
Source dataset
uspto-grants-2008_05
Patent number
US07375104B2

Reaction notes

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