反应详情

A suspension of 5.20 g (16.45 mmol) of 1-(2-nitrophenyl)cyclohexanol and 500 mg of Raney nickel in EtOH (70 mL) is hydrogenated at RT and under 3 bar hydrogen pressure for 4 hours. The catalyst is filtered off through CELITE® filter aid and the filtrate is evaporated down in vacuo. The residue is recrystallized from hexane. Yield: 1.53 g (49%); Rf=0.38 (silica gel, hexane/EtOAc 4:1); ESI-MS: [M+H−H2O]+=174.

1. filtrationThe catalyst is filtered off through CELITE®
2. filtrationfilter aid
3. customthe filtrate is evaporated down in vacuo
4. customThe residue is recrystallized from hexane