Cyclobutylamine → HCID 58617393, compound

Participants

Reaction Steps

E3 (67 mg, 0.11 mmol), cyclobutyl amine (14.7 μL, 0.17 mmol), and sodium triacetoxyborohydride (73 mg, 0.34 mmol) were stirred in dichloroethane at room temperature for 3 h. The reaction mixture was diluted with dichloromethane, then washed with saturated aqueous sodium bicarbonate and brine. It was dried over magnesium sulfate, filtered, concentrated in vacuo. Purified by chromatography (4% to 10% methanol with 0.1% ammonium hydroxide in dichloromethane), recovering 31 mg of E4.

Provenance & Evidence