HCID 58617415, compound → HCID 58617389, compound

Participants

Reaction Steps

E5 (33 mg, 0.048 mmol) was dissolved in methanol and degassed with nitrogen for 5 min. Palladium (10% wt. on C, 33 mg) was added, then the reaction was placed under hydrogen atmosphere with a balloon. It was stirred for 2 h at room temperature, then filtered through Celite, and concentrated in vacuo. Purified by reverse-phase HPLC to yield 16 mg, a colorless solid, 4. MS (MH+): 658.3. 1H NMR (400 MHz; CDCl3; T=298 K): δ 7.40 (m, 1H), 7.14 (m, 4H), 6.89 (dd, 2H, J=8.7, 22.9 Hz), 5.21 (m, 1H), 4.81 (m, 1H), 4.02 (dd, 2H, J=15.9, 9.9 Hz), 3.57 (d, 1H, J=9.6 Hz), 3.39 (m, 2H), 3.21 (m, 2H), 3.03 (m, 1H), 2.76 (d, 1H, J=14.8 Hz), 2.56 (m, 2H), 2.20 (dd, 1H, J=25.0, 15.8 Hz), 1.97 (d, 3H, J=11.2 Hz), 1.88 (s, 3H), 1.74 (m, 3H), 1.64 (m, 3H), 1.40 (d, 4H, J=10.8 Hz), 1.30 (d, 6H, J=18.8 Hz) ppm.

Provenance & Evidence