HCID 46883308, compound → HCID 69199992, compound

Participants

Reaction Steps

F2 (665 mg, 1.09 mmol) was dissolved in methanol and degassed with nitrogen for 5 min. Palladium (10% wt. on C, 665 mg) was added, then the reaction was placed under hydrogen atmosphere with a balloon. The reaction stirred overnight at room temperature, then it was filtered through Celite, and concentrated in vacuo. Purified by reverse-phase HPLC to yield 280 mg of a colorless solid, 5. MS (MH+): 644.5. 1H NMR (400 MHz; CDCl3; T=298 K): δ 7.10 (m, 7H), 5.08 (broad s, 1H), 4.70 (dd, 1H, J=11.2, 5.0 Hz), 4.01 (quint, 2H, 6.8 Hz), 3.67 (broad s, 1H), 3.42 (s, 3H), 3.14 (broad s, 3H), 2.67 (broad m, 3H), 2.55 (t, 3H, J=6.2 Hz), 2.29 (broad s, 2H), 1.90 (dd, 3H, J=5.6, 2.5 Hz), 1.39 (t, 6H, J=6.9 Hz), 1.25 (d, 6H, 6.4 Hz) ppm.

Provenance & Evidence