4-(4-Fluoro-benzyl)-piperidine → 2-[4-(4-Fluorobenzyl)piperidin-1-carbonyl]-1,5-dihydro-8-oxa-1,5-diaza-cyclopenta[b]naphthalene-6-one

HRID 2223220Notes

Reaction equation

HRID 2223220 reaction equation
[O:1]=[C:2]1[CH2:11][O:10][C:9]2[CH:8]=[C:7]3[NH:12][C:13]([C:15]([OH:17])=O)=[CH:14][C:6]3=[CH:5][C:4]=2[NH:3]1.[F:18][C:19]1[CH:31]=[CH:30][C:22]([CH2:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:21][CH:20]=1>C(OCC)C>[F:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][CH:24]2[CH2:25][CH2:26][N:27]([C:15]([C:13]3[NH:12][C:7]4=[CH:8][C:9]5[O:10][CH2:11][C:2](=[O:1])[NH:3][C:4]=5[CH:5]=[C:6]4[CH:14]=3)=[O:17])[CH2:28][CH2:29]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 22350172HCID 22350172, compound

Product 1

HCID 223501942-[4-(4-Fluorobenzyl)piperidin-1-carbonyl]-1,5-dihydro-8-oxa-1,5-diaza-cyclopenta[b]naphthalene-6-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 6-oxo-1,5,6,7-tetrahydro-8-oxa-1,5-diaza-cyclopenta[b]naphthalene-2-carboxylic acid and 4-(4-fluorobenzyl)piperidine according to the method described in Example 1/c. Mp.: 219-226° C. (diethyl ether).

Sources & evidence

ORD record
ord-896e49e0eafd47dda94daccceab3c657
Source dataset
uspto-grants-2008_05
Patent number
US07375116B2

Reaction notes

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