Dimethylformamide → HCID 69224107, compound

Participants

Reaction Steps

To an oven dried 250 mL flask, 2.77 g of 2A (1 eq), 1.85 g Zn(CN)2 (1.8 eq), 68 mg of Zn powder and 160 mg (0.02 eq) of Pd2 dba3 were added followed by 75 mL of dry DMF. Under magnetic stirring, 1.07 mL of 10% hexane solution (0.04 eq) of PtBu3 was added and the mixture was stirred at room temperature for a period of 30 min followed by heating at 100° C. for another 35 min. The mixture was cooled to room temperature and poured into ice water. The solid was collected, washed with water and dried. The product was dissolved in THF, filtered and concentrated to dryness to produce crude 3 that was used without purification in the next step.

Provenance & Evidence