HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(6-Aminopyridin-3-yl)-2-{[benzyl(hydroxy)phosphoryl]methyl}propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-[Benzyl(hydroxy)phosphoryl]-2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)propanoic acid | HCID 68802369 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(6-Aminopyridin-3-yl)-2-{[benzyl(hydroxy)phosphoryl]methyl}propanoic acid | HCID 68801646 | 68% |
Reaction Steps
3-[Benzyl(hydroxy)phosphoryl]-2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)propanoic acid (46 mg; 0.11 mmol) was dissolved in EtOAc (2 mL) and 1 mL of EtOAc, which had been saturated with HCl (g), was added. The reaction was stirred at room temperature overnight. The reaction mixture was concentrated to yield 25 mg (64%) of 3-(6-aminopyridin-3-yl)-2-{[benzyl(hydroxy)phosphoryl]methyl}propanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375121B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-f2105a79d5a64b07ac7357acce64e281 |
| Source note | uspto-grants-2008_05 |