反应详情

To a solution of 0.087 g (1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid tert-butyl ester in 1 ml of dichloromethane, 0.064 g of benzene sulfonyl chloride and 0.052 g of pyridine were added. The reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched by addition of 1 M HCl (1 ml) and extracted with dichloromethane. The organic layer was washed with saturated NaHCO3, dried (MgSO4) and evaporated on the rotary evaporator to yield 0.113 g (95%) of the product as a light yellow foam.

1. customThe reaction was quenched by addition of 1 M HCl (1 ml)
2. extractionextracted with dichloromethane
3. washThe organic layer was washed with saturated NaHCO3
4. dry with materialdried (MgSO4)
5. customevaporated on the rotary evaporator