Diethyl isopropylmalonate → N-(3,5-Difluoro-benzyl)-2-isopropyl-malonamic acid

HRID 2223253Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6]C(=O)C(C)C(O)=O.[CH:18]([CH:21]([C:27]([O:29]CC)=O)[C:22]([O:24]CC)=[O:23])([CH3:20])[CH3:19]>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:27](=[O:29])[CH:21]([CH:18]([CH3:19])[CH3:20])[C:22]([OH:24])=[O:23]

Participants

Reactant 2

HCID 12966Diethyl isopropylmalonate

HCID 21091473N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid

Product 1

HCID 69280641N-(3,5-Difluoro-benzyl)-2-isopropyl-malonamic acid

Procedure

N-(3,5-Difluoro-benzyl)-2-isopropyl-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl isopropyl-malonate.

Sources & evidence

ORD record: ord-e3bf16c655d244a983825dd5514835a6
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07375099B2

Reaction notes

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