HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3,5-Difluoro-benzyl)-2,2-dimethyl-malonamic acid → N-(3,5-Difluoro-benzyl)-N'-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2,2-dimethyl-malonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3,5-Difluoro-benzyl)-2,2-dimethyl-malonamic acid | HCID 21091472 | — |
| Reactant | HCID 69280666 | HCID 69280666 | — |
| Product | N-(3,5-Difluoro-benzyl)-N'-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2,2-dimethyl-malonamide | HCID 69280624 | — |
Reaction Steps
N-(3,5-Difluoro-benzyl)-N′-[2-(3,4-dihydro-1H-isoguinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2,2-dimethyl-malonamide. MS: m/e=559.3 (M+H+), was prepared in analogy to N-(3,5-difluoro-benzyl)-N′-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-methyl-malonamide (example 16) from N-(3,5-difluoro-benzyl)-2,2-dimethyl-malonamic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375099B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-716ac025070b413fb565f634ae80d5d8 |
| Source note | uspto-grants-2008_05 |