3-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one → N-(3,5-Difluoro-benzyl)-2-ethyl-N'-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-malonamide

HRID 2223265Notes

Reaction equation

HRID 2223265 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]([CH3:19])[C:3]1=[O:20].[F:21][C:22]1[CH:23]=[C:24]([CH:35]=[C:36]([F:38])[CH:37]=1)[CH2:25][NH:26][C:27](=[O:34])[CH:28]([CH2:32][CH3:33])[C:29](O)=[O:30]>>[F:21][C:22]1[CH:23]=[C:24]([CH:35]=[C:36]([F:38])[CH:37]=1)[CH2:25][NH:26][C:27](=[O:34])[CH:28]([CH2:32][CH3:33])[C:29]([NH:1][CH:2]1[C:3](=[O:20])[N:4]([CH3:19])[C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:8]1)=[O:30]

Participants

3

Reactant 2

HCID 27296813-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-oneHCID 69280647N-(3,5-Difluoro-benzyl)-2-ethyl-malonamic acid

Product 1

HCID 10481236N-(3,5-Difluoro-benzyl)-2-ethyl-N'-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-malonamide

Procedure

The title compound, MS: m/e=505.3 (M+H+), was prepared in analogy to example 16 from 3-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one and N-(3,5-difluoro-benzyl)-2-ethyl-malonamic acid.

Sources & evidence

ORD record
ord-94d56d0f4a4348fc9191670b5edb735a
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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