7-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one → HCID 10027577, compound

HRID 2223270Notes

Reaction equation

HRID 2223270 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]1[CH:21]=[C:22]([CH:32]=[C:33]([F:35])[CH:34]=1)[CH2:23][NH:24][C:25](=[O:31])[CH:26]([F:30])[C:27](O)=[O:28]>>[F:19][C:20]1[CH:21]=[C:22]([CH:32]=[C:33]([F:35])[CH:34]=1)[CH2:23][NH:24][C:25](=[O:31])[CH:26]([F:30])[C:27]([NH:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2)=[O:28]

Participants

3

Reactant 2

HCID 101986267-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-oneHCID 85987788HCID 85987788, compound

Product 1

HCID 10027577HCID 10027577, compound

Procedure

The title compound, MS: m/e=468.2 (M+H+), was prepared in analogy to example 16 from 7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and N-(3,5-difluoro-benzyl)-2-fluoro-malonamic acid.

Sources & evidence

ORD record
ord-a4a0d85a3f7d4bf3ab037a9fbd3daf5a
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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